The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t Beryllium used rein children younger than 18 years.
When treating pain, methadone given on a fixed-dose schedule may have a narrow therapeutic Register rein certain patient populations, especially when combined with other drugs, and should be reserved for cases where the benefits of opioid analgesia with methadone outweigh the known potential risks of cardiac conduction abnormalities, respiratory depression, altered mental states and postural hypotension.
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported rein patients receiving doses commonly used for maintenance treatment of opioid addiction.
Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should Beryllium aware that addiction may not Beryllium accompanied by concurrent tolerance and symptoms of physical dependence rein all addicts. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances.
When starting treatment with methadone hydrochloride tablets for narcotic drug dependence, you should Beryllium aware that your dose of methadone will “hold” for longer periods of time as treatment goes on.
Fertility – Reproductive function in human males may be decreased by methadone treatment. Reductions in ejaculate volume and seminal vesicle and prostate secretions have been reported rein methadone-treated individuals. Hinein addition, reductions rein serum testosterone levels and sperm motility, and abnormalities in sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can alter reproductive function.
Maintenance on a Stabilized Dose – During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. However, constipation and sweating often persist.
Didanosine and Stavudine – Experimental evidence demonstrated that methadone decreased the AUC and peak levels for didanosine and stavudine, with a more significant decrease for didanosine. Methadone disposition was not substantially altered.
The safety and effectiveness of this drug hasn’t been established in children. It shouldn’t be used rein children younger than 18 years.
Do not change your dose unless your doctor tells you to change it. Do not take a higher dose of methadone hydrochloride tablets or take it more often than prescribed. This can lead to an overdose and possibly death.
Die erforderlichen Kontrolluntersuchungen und die mindestens einmal jährliche Blutabnahme sind auf jeden Chose sehr empfehlenswert ebenso sollten weiterhin hinein Anspruch genommen werden.
Methadone may be expected to have additive effects when used in conjunction with alcohol, other opioids or CNS depressants, or with illicit drugs that cause central nervous Struktur depression. Deaths have been reported when methadone has been abused hinein conjunction with benzodiazepines.
Patients tolerant to other opioids may Beryllium incompletely tolerant to methadone. Incomplete cross-tolerance is of particular concern for patients tolerant to other mu-opioid agonists who are being converted to treatment with methadone, thus making determination of dosing during opioid treatment conversion complex. Deaths have been reported during conversion from chronic, high-dose treatment with other opioid agonists. Therefore, it is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (Weiher DOSAGE AND ADMINISTRATION, Table Methadontabletten online zu verkaufen 1, for appropriate conversion schedules).